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Cancer Lett. 2010 Jan 1;287(1):1-12. doi: 10.1016/j.canlet.2009.05.013. Epub 2009 May 31.

Plant lectins: potential antineoplastic drugs from bench to clinic.

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1
School of Life Sciences, Sichuan University, Chengdu 610064, China.

Abstract

Plant lectins, carbohydrate-binding proteins distributed widely in a variety of plant species, have drawn a rising attention for cancer biologists due to their remarkable anti-tumour properties. In this review, we present a brief outline of the up-to-date advances of plant lectins in elucidating their complex anti-cancer mechanisms implicated in apoptosis and autophagy. In addition, we further discuss the pre-clinical and clinical studies of plant lectins for their potential therapeutic applications. In conclusion, these inspiring findings would open a new perspective for plant lectins as potential antineoplastic drugs from bench to clinic.

PMID:
19487073
DOI:
10.1016/j.canlet.2009.05.013
[Indexed for MEDLINE]

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