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Expert Rev Anti Infect Ther. 2009 Jun;7(5):559-68. doi: 10.1586/eri.09.34.

Novel approaches in fighting herpes simplex virus infections.

Author information

1
Department of Pediatrics, Albert Einstein College of Medicine, Forchheimer 702, 1300 Morris Park Avenue, Bronx, NY 10461, USA. swilson@aecom.yu.edu

Abstract

The development of novel strategies to eradicate herpes simplex virus (HSV) is a global public health priority. While acyclovir and related nucleoside analogues provide successful modalities for treatment and suppression, HSV remains highly prevalent worldwide and is a major cofactor fueling the HIV epidemic. HSV is the predominant cause of genital ulcerative disease, and neonatal and sporadic infectious encephalitis. Asymptomatic shedding, which occurs more frequently than previously appreciated, contributes to viral transmission. Acyclovir resistance may be problematic for immunocompromised patients and highlights the need for new safe and effective agents. Ideally, vaccines to prevent infection, drugs to inhibit the establishment of or reactivation from latency, or vaginal microbicides to prevent sexual and perinatal transmission are needed to control the epidemic. This review summarizes current therapeutic options and strategies in development.

PMID:
19485796
PMCID:
PMC2730970
DOI:
10.1586/eri.09.34
[Indexed for MEDLINE]
Free PMC Article
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