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Opt Express. 2004 Aug 23;12(17):3996-4000.

Three-dimensional bioluminescence tomography with model-based reconstruction.

Abstract

A model-based image reconstruction method, bioluminescence tomography (BLT), is described. BLT has the potential to spatially resolve bioluminescence associated with gene expression in vivo, thus, offering a tomographic molecular imaging method. The three-dimensional spatial map of reporter genes is recovered using a diffusion equation model-based, finite element reconstruction algorithm. The imaging method is demonstrated using both numerical simulations and phantom experiments.

PMID:
19483937
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