Format

Send to

Choose Destination
Neuroreport. 2009 Jul 15;20(11):1019-22. doi: 10.1097/WNR.0b013e32832d30d9.

Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia.

Author information

1
Departments of aNeurobiology bPsychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, Alabama, USA. adamfunk@uab.edu

Abstract

Converging evidence suggests too few activation-ready N-methyl-D-aspartic acid (NMDA) receptor complexes in the postsynaptic density in schizophrenia. Postsynaptic density protein 95 (PSD95), Synaptic GTPase-activating protein (SynGAP), and Multiple PDZ domain protein (MUPP1) are integral components of the NMDA receptor signaling complex, and help facilitate signaling, trafficking, and stabilization. We hypothesized that deficits involving these molecules may contribute to the pathophysiology of schizophrenia. To test our hypothesis, we measured protein expression of PSD95, SynGAP, and MUPP1 in the anterior cingulate cortex and dorsolateral prefrontal cortex. We found decreased PSD95 expression in the anterior cingulate cortex. Antipsychotic medication analyses showed decreased SynGAP expression in the anterior cingulate cortex in patients off medication when analyzed against our comparison group. These data suggest that NMDA receptor complex formation, localization, and downstream signaling may be abnormal in schizophrenia.

PMID:
19483657
PMCID:
PMC3731946
DOI:
10.1097/WNR.0b013e32832d30d9
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wolters Kluwer Icon for PubMed Central
Loading ...
Support Center