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Optom Vis Sci. 2009 Jun;86(6):E653-8. doi: 10.1097/OPX.0b013e3181a6a237.

Development of rod function in term born and former preterm subjects.

Author information

1
Department of Ophthalmology, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. anne.fulton@childrens.harvard.edu

Abstract

PURPOSE:

To provide an overview of some of our electroretinographic (ERG) and psychophysical studies of normal development of rod function and their application to retinopathy of prematurity (ROP).

METHODS:

ERG responses to full-field stimuli were recorded from dark adapted subjects. Rod photoreceptor sensitivity (SROD) was calculated by fit of a biochemical model of the activation of phototransduction to the ERG a-wave. Dark adapted psychophysical thresholds for detecting 2 degrees spots in parafoveal (10 degrees eccentric) and peripheral (30 degrees eccentric) retina were measured and the difference between the thresholds, Delta10-30, was examined as a function of age. SROD and Delta10-30 in term born and former preterm subjects were compared.

RESULTS:

In term born infants, (1) the normal developmental increase in SROD changes proportionately with the amount of rod visual pigment, rhodopsin, and (2) rod-mediated function in central retina is immature compared with that in peripheral retina. In subjects born prematurely, deficits in SROD persist long after active ROP has resolved. Maturation of rod-mediated thresholds in the central retina is prolonged by mild ROP.

CONCLUSIONS:

Characterization of the development of normal rod and rod-mediated function provides a foundation for understanding ROP.

PMID:
19483509
PMCID:
PMC2822655
DOI:
10.1097/OPX.0b013e3181a6a237
[Indexed for MEDLINE]
Free PMC Article
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