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Bioorg Med Chem Lett. 2009 Aug 1;19(15):4437-40. doi: 10.1016/j.bmcl.2009.05.048. Epub 2009 May 18.

Bicyclic cyanothiazolidines as novel dipeptidyl peptidase 4 inhibitors.

Author information

1
Phenomix Corporation, 5871 Oberlin Drive, Suite 200, San Diego, CA 92121, USA. juan.betancort@phenomixcorp.com

Abstract

The synthesis and biochemical evaluation of novel cyanothiazolidine inhibitors of dipeptidyl peptidase 4 (DPP4) is described. Their main structural feature is a constrained bicyclic core that prevents the intramolecular formation of inactive cyclic species. The inhibitors show good to moderate biochemical potency against DPP4 and display distinct selectivity profiles towards DPP7, DPP8 and DPP9 depending on their substitution.

PMID:
19482472
DOI:
10.1016/j.bmcl.2009.05.048
[Indexed for MEDLINE]

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