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Thromb Res. 2009 Dec;124(6):667-71. doi: 10.1016/j.thromres.2009.04.021. Epub 2009 May 30.

Pharmacodynamics of low molecular weight heparin in patients undergoing bariatric surgery: a prospective, randomised study comparing two doses of parnaparin (BAFLUX study).

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1
Ospedale Civile, Piacenza, Italy. d.imberti@ausl.pc.it

Abstract

BACKGROUND:

The optimal dose of low-molecular-weight-heparin (LMWH) to prevent venous thromboembolism (VTE) after bariatric surgery remains controversial.

AIM:

The aim of this study was to evaluate the pharmacodynamic parameters of two doses of the LMWH parnaparin administered to patients undergoing bariatric surgery.

METHODS:

Patients were enrolled in a multicentre, open label, pilot study and were randomised to receive 4250 IU/day [n=36; 30 females; median age: 38 years (23-56); median BMI: 46.7 Kg/m(2) (36.5-58.8)] or 6400 IU/day [n=30; 24 females; median age: 42 years (22-63); median BMI: 43.7 Kg/m(2) (36.1-64.1)] of parnaparin s.c. for 7-11 days. The pharmacodynamic effects of parnaparin were analysed by measuring the anti Factor Xa activity on day 0 (12 hours after the first parnaparin injection), day 4 and day 6 after surgery (before and 4 hours after parnaparin administration).

RESULTS:

In 98.3% of patients receiving 4250 IU/day the peak anti-Xa levels were in the range of 0.1-0.4 IU/ml. Higher anti-Xa levels were observed in patients receiving 6400 IU/day: in 62.3% of these patients the peak anti-Xa levels were greater than 0.4 IU/ml. The anti-Xa levels measured 4 hours after injection on days 4 and 6 were not statistically correlated with BMI for either dose of parnaparin (p=0.077 and p=0.401 for 4250 or 6400 IU/day, respectively).

CONCLUSION:

The dose of 4250 IU/day seems adequate to achieve prophylactic anti-Xa levels in morbid obese patients undergoing bariatric surgery. Conversely, most of the patients receiving 6.400 IU/day show anti-Xa levels higher than the recommended prophylactic values.

PMID:
19482341
DOI:
10.1016/j.thromres.2009.04.021
[Indexed for MEDLINE]
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