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Bioorg Med Chem Lett. 2009 Jul 1;19(13):3405-9. doi: 10.1016/j.bmcl.2009.05.040. Epub 2009 May 18.

Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors.

Author information

1
Schering-Plough Research Institute, 320 Bent Street, Cambridge, MA 02141, USA. brian.lahue@spcorp.com

Abstract

Substituted benzimidazoles were profiled as inhibitors of kinesin spindle protein (KSP), an increasingly important target for the development of anticancer drugs. This series demonstrated the monoastral phenotypic response and was found to be active in both enzymatic and cellular-based assays.

PMID:
19481450
DOI:
10.1016/j.bmcl.2009.05.040
[Indexed for MEDLINE]

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