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Int J Biochem Cell Biol. 2009 Oct;41(10):1972-6. doi: 10.1016/j.biocel.2009.05.013. Epub 2009 May 27.

Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex.

Author information

1
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Abstract

Calcium oscillations control mitochondrial motility along the microtubules and in turn, support on-demand distribution of mitochondria. However, the mechanism mediating the Ca(2+) effect remained a mystery. Recently, several papers reported on the Ca(2+)-dependent regulation of mitochondrial dynamics by a Miro-Milton complex linking mitochondria to kinesin motors. Both mitochondrial motility and fusion-fission dynamics seem to be sensitive to a Ca(2+)-dependent switch by this complex. Evidence is emerging that calcium signaling through Miro-Milton is central to coordination of the local oxidative metabolism with the energy demands and protection against Ca(2+)-induced cell injury.

PMID:
19481172
PMCID:
PMC2742205
DOI:
10.1016/j.biocel.2009.05.013
[Indexed for MEDLINE]
Free PMC Article

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