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J Altern Complement Med. 2009 Jun;15(6):669-72. doi: 10.1089/acm.2008.0508.

Clinical evaluation of an Indian polyherbal topical formulation in the management of eczema.

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1
N. H. L. Medical College & V. S. Hospital, Ahmedabad, India.

Abstract

OBJECTIVES:

To evaluate the efficacy and safety of a topical application of Herbavate cream (Troikaa Pharmaceuticals Ltd, Ahmedabad, India), a polyherbal formulation in the management of outpatients with eczema.

DESIGN:

This was an open label design.

SUBJECTS AND SETTING:

One hundred and fifty (150) outpatients with a clinical diagnosis of eczema and meeting the eligibility criteria used topical Herbavate twice daily for 4 weeks. Change in symptom score for eczema (erythema, scaling, thickening, and itching) was assessed weekly using a 4-point score. The trial was carried out at Civil Hospital, Ahmedabad, Seth V.S. Hospital, Ahmedabad, and Stanley Medical College, Chennai.

OUTCOME MEASURES:

The primary outcome measure was a change in symptom score at 4 weeks as compared to baseline scores. The secondary outcome measure was a weekly change in symptom score as compared to the previous visit. Local tolerance was judged by development of side effects at site of application.

RESULTS:

Clinical improvement in symptom score at the end of study as compared to baseline was significant for all symptoms assessed (p < 0.001). Significant reduction in symptoms scores was observed from end of week 1. Local tolerance was good, with only 5 patients reporting side effects that improved with continued use. No patient withdrew due to side effects.

CONCLUSIONS:

Herbavate, a topical polyherbal formulation, appears to an attractive alternate option for the management of outpatients with eczema.

PMID:
19480603
DOI:
10.1089/acm.2008.0508
[Indexed for MEDLINE]

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