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Int J Radiat Biol. 2009 Jul;85(7):614-21. doi: 10.1080/09553000902954504.

Is there a specific mutation of p53 gene due to radon exposure? A systematic review.

Author information

1
Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain. alberto.ruano@usc.es

Abstract

PURPOSE:

To review the existing literature analysing the influence of radon exposure on mutations in tumour protein 53 gene (TP53) in lung cancer patients.

MATERIAL AND METHODS:

Medline and EMBASE databases along with the International Agency for Research on Cancer (IARC) monographies were revised. Studies that had radon concentration as exposure variable and TP53 mutations as a result variable were included.

RESULTS:

Eight studies were obtained, with a total of 578 individuals. They had been carried out on miners and on general population. A 26% of the miners' tumours had a mutation in gene TP53, versus a 24% in the population exposed to residential radon. A predominance of the AGG(ARG)--> ATG(MET) (Arginine to Methionine) mutation in miners was observed.

CONCLUSIONS:

The available results are not consistent in order to support the existence of a radon hotspot in TP53 gene. Future research should focus at least on exons 5 to 8, where most of the mutation clusters in lung tumours are observed.

PMID:
19479602
DOI:
10.1080/09553000902954504
[Indexed for MEDLINE]

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