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PLoS One. 2009 May 29;4(5):e5730. doi: 10.1371/journal.pone.0005730.

Prion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assay.

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1
Department of Infectology, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America.

Abstract

Prion strain identification has been hitherto achieved using time-consuming incubation time determinations in one or more mouse lines and elaborate neuropathological assessment. In the present work, we make a detailed study of the properties of PrP-overproducing Tga20 mice. We show that in these mice the four prion strains examined are rapidly and faithfully amplified and can subsequently be discriminated by a cell-based procedure, the Cell Panel Assay.

PMID:
19478942
PMCID:
PMC2684634
DOI:
10.1371/journal.pone.0005730
[Indexed for MEDLINE]
Free PMC Article
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