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Epidemiology. 2009 Sep;20(5):689-98. doi: 10.1097/EDE.0b013e3181a7128f.

Ambient air pollution and preterm birth: a time-series analysis.

Author information

1
Rollins School of Public Health, Emory University, Atlanta, GA, USA. ldarrow@sph.emory.edu

Abstract

BACKGROUND:

An emerging body of evidence suggests that ambient levels of air pollution during pregnancy are associated with preterm birth.

METHODS:

To further investigate these relationships we used vital record data to construct a retrospective cohort of 476,489 births occurring between 1994 and 2004 in 5 central counties of metropolitan Atlanta. Using a time-series approach, we examined aggregated daily counts of preterm birth in relation to ambient levels of carbon monoxide, nitrogen dioxide, sulfur dioxide, ozone, particulate matter <10 microm in diameter (PM10), particulate matter <2.5 microm in diameter (PM2.5), and speciated PM measurements. Daily pollutant levels in 5-county Atlanta were characterized using a population-weighted spatial average of air quality monitors in the study area. We also examined ambient concentrations at individual monitors in analyses limited to mothers with residential geocodes within 4 miles of each monitor. Relationships between average pollution levels during 3 gestational windows of interest were modeled using Poisson generalized linear models. Results were adjusted for seasonal and long-term time trends.

RESULTS:

Although most results were null, there were 3 positive associations between ambient pollution levels and preterm birth in the 4-mile capture-area analyses. Daily preterm birth rates were associated with average NO2 concentrations in the preceding 6 weeks and with average PM2.5 sulfate and PM2.5 water-soluble metal concentrations in the preceding week.

CONCLUSIONS:

Results provide limited support for late-pregnancy effects of ambient air pollution on preterm birth.

PMID:
19478670
PMCID:
PMC3780365
DOI:
10.1097/EDE.0b013e3181a7128f
[Indexed for MEDLINE]
Free PMC Article

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