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Int J Cardiol. 2010 Oct 29;144(3):394-8. doi: 10.1016/j.ijcard.2009.04.048. Epub 2009 May 27.

Low serum LDL cholesterol in patients with type 2 diabetes: an analysis on two different patient populations.

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1
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.

Abstract

BACKGROUND:

Patients with type 2 diabetes (T2DM) typically exhibit a pattern of dyslipidemia with high triglycerides, low HDL cholesterol, and small LDL particles. We aimed at investigating whether also LDL cholesterol levels are altered in diabetic patients.

METHODS:

Lipid panels were obtained in a consecutive series of angiographied coronary patients (n=750), and in a large sample of hypertensive outpatients (n=5949).

RESULTS:

T2DM patients in the cohort of coronary patients (n=164; 21.9%) had significantly higher triglycerides (203±138 vs. 153±91 mg/dl; p<0.001), lower HDL cholesterol (44±14 vs. 50±14 mg/dl; p<0.001), lower apolipoprotein A1 (140±28 vs. 148±28 mg/dl; p=0.002), lower total cholesterol (211±48 vs. 220±42 mg/dl; p=0.006) and, importantly, lower LDL cholesterol (122±38 vs. 134±35 mg/dl; p<0.001) than non-diabetic subjects. Whereas apolipoprotein B was similar in T2DM patients as in non-diabetic subjects (113±26 vs. 114±25 mg/dl; p=0.648), the LDL cholesterol/apolipoprotein B ratio was significantly lower (1.08±0.24 vs. 1.18±0.21; p<0.001) and LDL particles were significantly smaller (257±7 vs. 259±6 Å; p<0.001) in T2DM patients. Also among the hypertensive subjects, diabetic patients (n=1632; 27.3%) besides higher triglycerides (173±70 vs. 151±65 mg/dl; p<0.001) and lower HDL cholesterol (53±17 vs. 57±19 mg/dl; p<0.001) exhibited lower total cholesterol (216±44 vs. 222±41 mg/dl; p<0.001) and lower LDL cholesterol (127±40 vs. 136±37 mg/dl; p<0.001) than non-diabetic subjects.

CONCLUSIONS:

Both among angiographied coronary patients and hypertensive outpatients, LDL cholesterol is significantly lower in T2DM patients than in non-diabetic individuals.

PMID:
19477539
DOI:
10.1016/j.ijcard.2009.04.048
[Indexed for MEDLINE]

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