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Cancer Cell. 2009 Jun 2;15(6):539-50. doi: 10.1016/j.ccr.2009.03.027.

Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.

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1
Department of Systems Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Erratum in

  • Cancer Cell. 2009 Aug 4;16(2):172.

Abstract

Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.

PMID:
19477432
PMCID:
PMC4157573
DOI:
10.1016/j.ccr.2009.03.027
[Indexed for MEDLINE]
Free PMC Article

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