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Cancer Cell. 2009 Jun 2;15(6):457-9. doi: 10.1016/j.ccr.2009.05.003.

Mammary tumorigenesis through LPA receptor signaling.

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1
Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Abstract

Lysophosphatidic acid (LPA) is a lipid growth factor that is produced by an extracellular phospholipase, termed autotaxin (ATX), and acts via G protein-coupled receptors. In this issue of Cancer Cell, Liu et al. show that transgenic overexpression of ATX or LPA receptors leads to invasive and metastatic mammary cancer.

PMID:
19477423
DOI:
10.1016/j.ccr.2009.05.003
[Indexed for MEDLINE]
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