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Cancer Cell. 2009 Jun 2;15(6):455-7. doi: 10.1016/j.ccr.2009.05.006.

Telomere uncapping, chromosomes, and carcinomas.

Author information

1
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Data from mouse models and from human cancers have supported the idea that telomere shortening leads to chromosomal instability and epithelial carcinogenesis. In this issue of Cancer Cell, Else et al. demonstrate that telomere uncapping-altering a protein that protects chromosome ends without shortening telomeres-also results in epithelial cancers.

PMID:
19477422
DOI:
10.1016/j.ccr.2009.05.006
[Indexed for MEDLINE]
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