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FEBS J. 2009 May;276(9):2469-77. doi: 10.1111/j.1742-4658.2009.06985.x. Epub 2009 Mar 24.

Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.

Author information

1
Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA.

Abstract

Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part, through an evolved sensitivity of some peroxiredoxins towards peroxide-mediated inactivation in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of 'typical 2-Cys' peroxiredoxins and of the biological roles played by these important enzymes in oxidative stress and nonstress-related cellular signaling. New evidence suggests localized peroxide buildup plays a role in nonstress-related signaling.

PMID:
19476488
PMCID:
PMC2747500
DOI:
10.1111/j.1742-4658.2009.06985.x
[Indexed for MEDLINE]
Free PMC Article

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