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Am J Primatol. 2009 Sep;71(9):794-801. doi: 10.1002/ajp.20705.

Neuroprotective effects of estrogen therapy for cognitive and neurobiological profiles of monkey models of menopause.

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  • 1Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. mlvoytko@wfubmc.edu

Abstract

Many postmenopausal women question whether to start or continue hormone therapy because of recent clinical trial negative results. However, evidence from other studies of postmenopausal women, and from studies in menopausal monkeys, indicate that estrogen has neurocognitive protective effects, particularly when therapy is initiated close to the time of menopause before neural systems become increasingly compromised with age. In this review, we present studies of menopausal women and female monkeys that support the concept that estrogen therapies protect both cognitive function and neurobiological processes.

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