Ipilimumab-induced hypophysitis: MR imaging findings

AJNR Am J Neuroradiol. 2009 Oct;30(9):1751-3. doi: 10.3174/ajnr.A1623. Epub 2009 May 27.

Abstract

Ipilimumab is a promising new immunotherapeutic antineoplastic agent with clinical activity in the treatment of metastatic melanoma and renal cell carcinoma. With advances in immunotherapy, however, a host of new side effects related to the mechanism of action of these drugs has appeared. At our institution, 3 patients presented with hypophysitis, which was attributed to an autoimmune process based on the documented relationship of the drug to other autoimmune phenomena and significant and rapid improvement with discontinuation of the drug and addition of steroids. We present the imaging findings in 3 patients with presumed ipilimumab-induced hypophysitis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal / adverse effects*
  • Antineoplastic Agents / adverse effects
  • Brain / drug effects*
  • Brain / pathology*
  • Female
  • Humans
  • Ipilimumab
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Pituitary Diseases / chemically induced*
  • Pituitary Diseases / pathology*

Substances

  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Ipilimumab