Format

Send to

Choose Destination
DNA Repair (Amst). 2009 Sep 2;8(9):1068-76. doi: 10.1016/j.dnarep.2009.04.007. Epub 2009 May 26.

Choreography of recombination proteins during the DNA damage response.

Author information

1
Department of Biology, University of Copenhagen, Ole Maaloees Vej 5, DK-2200 Copenhagen N, Denmark. mlisby@bio.ku.dk

Abstract

Genome integrity is frequently challenged by DNA lesions from both endogenous and exogenous sources. A single DNA double-strand break (DSB) is lethal if unrepaired and may lead to loss of heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main causes of cancer and other genetic diseases. Consequently, DNA double-strand break repair (DSBR) is an important process in all living organisms. DSBR is also the driving mechanism in most strategies of gene targeting, which has applications in both genetic and clinical research. Here we review the cell biological response to DSBs in mitotically growing cells with an emphasis on homologous recombination pathways in yeast Saccharomyces cerevisiae and in mammalian cells.

PMID:
19473884
PMCID:
PMC2729071
DOI:
10.1016/j.dnarep.2009.04.007
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center