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J Clin Virol. 2009 Aug;45(4):300-3. doi: 10.1016/j.jcv.2009.04.005. Epub 2009 May 26.

No detection of human bocavirus in amniotic fluid samples from fetuses with hydrops or isolated effusions.

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1
Laboratory Prof. Enders and Partners & Institute of Virology, Infectious Diseases and Epidemiology, Rosenbergstrasse 85, D-70193 Stuttgart, Germany. mender@labor-enders.de

Abstract

BACKGROUND:

Human bocavirus (HBoV) is a recently identified parvovirus associated with respiratory disease in infants. Animal bocaviruses have been shown to cause intrauterine infection, fetal anasarca and abortion in late gestation.

OBJECTIVES:

To investigate whether HBoV infection is associated with fetal hydrops, fetal anemia or isolated fetal effusions.

STUDY DESIGN:

We determined the prevalence of HBoV and parvovirus B19 (B19) DNA in amniotic fluid samples from fetuses with hydrops, anemia or isolated effusions using different real-time PCR protocols, and the HBoV IgG and IgM positivity rate in pregnant women with fetal hydrops or normal ultrasound findings by a non-commercial virus-like particle-based enzyme immunoassay.

RESULTS:

None of 87 amniotic fluid samples tested was HBoV DNA positive. Twelve of 60 fetuses with hydrops or anemia were found B19 DNA positive. Anti-HBoV IgG antibodies were detected in 100% (19/19) and 94% (47/50) of serum samples from pregnant women with fetal hydrops and normal ultrasound findings, respectively. All serum samples were found negative for anti-HBoV IgM.

CONCLUSION:

We suggest that HBoV is not a common cause of fetal hydrops, anemia or isolated effusions. This has to be confirmed by further studies of proven gestational HBoV infection.

PMID:
19473872
DOI:
10.1016/j.jcv.2009.04.005
[Indexed for MEDLINE]
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