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Eur J Neurol. 2009 Aug;16(8):909-11. doi: 10.1111/j.1468-1331.2009.02621.x. Epub 2009 Mar 31.

GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.

Author information

1
Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. jasinskamyga.barbara@mayo.edu

Abstract

BACKGROUND AND PURPOSE:

A single nucleotide polymorphism in the 3'-untranslated region of the progranulin gene (GRN; 3'UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN.

METHODS:

As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland.

RESULTS:

No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis).

CONCLUSIONS:

This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.

[Indexed for MEDLINE]

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