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ACS Nano. 2009 Jun 23;3(6):1477-84. doi: 10.1021/nn9003346.

High throughput single nanoparticle spectroscopy.

Author information

1
La Jolla Bioengineering Institute, 505 Coast Boulevard South, La Jolla, CA 92037, USA.

Abstract

Progress in the development and application of nanoengineered systems is limited by the availability of quantitative measurement techniques. For the engineering of nanoparticle (NP)-based systems, single NP characterization is essential, but existing methods are slow and low throughput. We demonstrate a flow spectroscopy technique capable of analyzing hundreds of nanoparticles per second and use this technique for the high throughput analysis of nanoparticle surface-enhanced resonant Raman scattering (SERRS) tags. By measuring Rayleigh and Raman scattering from thousands of individual tags, tag preparations can be characterized based on their brightness and uniformity. The rapid analysis of individual nanoparticles using high spectral resolution flow spectroscopy will be useful in many areas of nanoengineering.

PMID:
19472989
PMCID:
PMC2730202
DOI:
10.1021/nn9003346
[Indexed for MEDLINE]
Free PMC Article

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