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J Cell Physiol. 2009 Sep;220(3):548-52. doi: 10.1002/jcp.21813.

Regulation of DGK-theta.

Author information

1
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. btusekine@jhmi.edu

Abstract

Diacylglycerol kinases are important regulators of lipid signaling and, consequently, important regulators of many diglyceride-dependent and PA-dependent proteins. Research over the last twenty years has clearly demonstrated that individual DGK isoforms can be connected with disparate cellular processes, indicating the presence of a sophisticated regulatory network for diglyceride and phosphatidic acid signaling through the regulation of individual DGK isoforms. This review presents the progress on the characterization of a primarily neuronal isoform DGK-theta, and examines current data on the primary structure, regulation and potential cellular functions of this enzyme.

PMID:
19472209
DOI:
10.1002/jcp.21813
[Indexed for MEDLINE]

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