Format

Send to

Choose Destination
See comment in PubMed Commons below
Nucl Recept Signal. 2009 May 8;7:e005. doi: 10.1621/nrs.07005.

Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).

Author information

1
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Functional Genomics, INSERM U596, CNRS UMR7104, Université Louis Pasteur de Strasbourg, Strasbourg, France. cegly@igbmc.fr

Abstract

Nuclear retinoic acid receptors (RARs) are transcriptional regulators controlling the expression of specific subsets of genes in a ligand-dependent manner. The basic mechanism for switching on transcription of cognate target genes involves RAR binding at specific response elements and a network of interactions with coregulatory protein complexes, the assembly of which is directed by the C-terminal ligand-binding domain of RARs. In addition to this scenario, new roles for the N-terminal domain and the ubiquitin-proteasome system recently emerged. Moreover, the functions of RARs are not limited to the regulation of cognate target genes, as they can transrepress other gene pathways. Finally, RARs are also involved in nongenomic biological activities such as the activation of translation and of kinase cascades. Here we will review these mechanisms, focusing on how kinase signaling and the proteasome pathway cooperate to influence the dynamics of RAR transcriptional activity.

PMID:
19471584
PMCID:
PMC2686084
DOI:
10.1621/nrs.07005
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nuclear Receptor Signaling Icon for PubMed Central
    Loading ...
    Support Center