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Nat Rev Neurosci. 2009 Jun;10(6):423-33. doi: 10.1038/nrn2651.

Stress, memory and the amygdala.

Author information

1
Department of Neuroscience, University Medical Center Groningen, University of Groningen, the Netherlands. b.roozendaal@med.umcg.nl

Abstract

Emotionally significant experiences tend to be well remembered, and the amygdala has a pivotal role in this process. But the efficient encoding of emotional memories can become maladaptive - severe stress often turns them into a source of chronic anxiety. Here, we review studies that have identified neural correlates of stress-induced modulation of amygdala structure and function - from cellular mechanisms to their behavioural consequences. The unique features of stress-induced plasticity in the amygdala, in association with changes in other brain regions, could have long-term consequences for cognitive performance and pathological anxiety exhibited in people with affective disorders.

PMID:
19469026
DOI:
10.1038/nrn2651
[Indexed for MEDLINE]

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