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Nat Rev Neurosci. 2009 Jun;10(6):397-409. doi: 10.1038/nrn2647.

Neural regulation of endocrine and autonomic stress responses.

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  • 1Department of Psychiatry, University of Cincinnati, Ohio 45237-0506, USA.

Abstract

The survival and well-being of all species requires appropriate physiological responses to environmental and homeostatic challenges. The re- establishment and maintenance of homeostasis entails the coordinated activation and control of neuroendocrine and autonomic stress systems. These collective stress responses are mediated by largely overlapping circuits in the limbic forebrain, the hypothalamus and the brainstem, so that the respective contributions of the neuroendocrine and autonomic systems are tuned in accordance with stressor modality and intensity. Limbic regions that are responsible for regulating stress responses intersect with circuits that are responsible for memory and reward, providing a means to tailor the stress response with respect to prior experience and anticipated outcomes.

PMID:
19469025
PMCID:
PMC4240627
DOI:
10.1038/nrn2647
[PubMed - indexed for MEDLINE]
Free PMC Article
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