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Cell Mol Life Sci. 2009 Sep;66(17):2819-33. doi: 10.1007/s00018-009-0048-9. Epub 2009 May 26.

Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation.

Author information

1
Natural Products and Cancer Biology Program, Cancer Research Center, University of Hawaii at Manoa, Honolulu, HI 96813, USA. vsu@crch.hawaii.edu

Abstract

The ubiquitin-proteasome pathway of protein degradation is one of the major mechanisms that are involved in the maintenance of the proper levels of cellular proteins. The regulation of proteasomal degradation thus ensures proper cell functions. The family of proteins containing ubiquitin-like (UbL) and ubiquitin-associated (UBA) domains has been implicated in proteasomal degradation. UbL-UBA domain containing proteins associate with substrates destined for degradation as well as with subunits of the proteasome, thus regulating the proper turnover of proteins.

PMID:
19468686
PMCID:
PMC2725189
DOI:
10.1007/s00018-009-0048-9
[Indexed for MEDLINE]
Free PMC Article

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