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Pathobiology. 2009 May;76(3):141-8. doi: 10.1159/000209392. Epub 2009 May 19.

p16ink4a is a surrogate marker for high-risk and malignant cervical lesions in the presence of human papillomavirus.

Author information

1
Division of Molecular Medicine, Regional Cancer Center, Thiruvananthapuram, India. rcc.lakshmi@gmail.com

Abstract

OBJECTIVE:

To strengthen the role of high-risk human papillomaviruses (HPVs) in the development of cervical cancer, and the association between HPV and the cell cycle inhibitor gene p16ink4a in cervical carcinogenesis.

METHODS:

In this study, the association between p16ink4a and the presence of HPV DNA in cervical lesions was investigated in a total of 177 cervical biopsies classified as benign (n = 42), low-grade squamous intraepithelial lesions (LSIL; n = 34), high-grade squamous intraepithelial lesions (HSIL; n = 48) and invasive cancer (n = 53). p16ink4a expression was analyzed by immunohistochemistry while HPV DNA was localized by in situ hybridization.

RESULTS:

No significant association was found between p16ink4a expression and HPV presence in benign and LSIL samples. In HSIL and invasive cancer, a significant association was found between p16ink4a overexpression and the presence of HPV DNA.

CONCLUSION:

Immunohistochemical p16ink4a expression is associated with HPV infection in HSIL and cervical cancer, suggesting a role of p16 as a biomarker of HPV-associated cervical lesions.

PMID:
19468254
DOI:
10.1159/000209392
[Indexed for MEDLINE]
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