Format

Send to

Choose Destination
Arq Bras Endocrinol Metabol. 2009 Mar;53(2):281-7.

HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS).

Author information

1
Laboratório de Investigação em Metabolismo e Diabetes, Instituto Nacional de Ciência e Tecnologia, Rua Carlos Chagas 420, Campinas, SP, Brazil. bgeloneze@terra.com.br

Abstract

OBJECTIVE:

To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS.

METHODS:

Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample.

RESULTS:

In the healthy group, HOMA-IR indexes were associated with central obesity, triglycerides and total cholesterol (p < 0.001). The cut-off values for IR were: HOMA1-IR > 2.7 and HOMA2-IR > 1.8; and, for MS were: HOMA1-IR > 2.3 (sensitivity: 76.8%; specificity: 66.7%) and HOMA2-IR > 1.4 (sensitivity: 79.2%; specificity: 61.2%).

CONCLUSION:

The cut-off values identified for HOMA1-IR and HOMA2-IR indexes have a clinical and epidemiological application for identifying IR and MS in Westernized admixtured multi-ethnic populations.

PMID:
19466221
DOI:
10.1590/s0004-27302009000200020
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center