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Immunity. 2009 May;30(5):616-25. doi: 10.1016/j.immuni.2009.04.009.

Control of regulatory T cell lineage commitment and maintenance.

Author information

1
Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. josefows@mskcc.org

Abstract

Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune responses against self and foreign antigens and commensal microorganisms. Sustained expression of the transcription factor Foxp3, a key distinguishing feature of Treg cells, is required for their differentiation and suppressor function. In addition, Foxp3 expression prevents deviation of Treg cells into effector T cell lineages and confers dependence of Treg cell survival and expansion on growth factors, foremost interleukin-2, provided by activated effector T cells. In this review we discuss Treg cell differentiation and maintenance with a particular emphasis on molecular regulation of Foxp3 expression, arguably a key to mechanistic understanding of biology of regulatory T cells.

PMID:
19464984
PMCID:
PMC4410181
DOI:
10.1016/j.immuni.2009.04.009
[Indexed for MEDLINE]
Free PMC Article

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