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Gait Posture. 2009 Aug;30(2):197-200. doi: 10.1016/j.gaitpost.2009.04.009. Epub 2009 May 22.

A multivariate statistical ranking of clinical and gait measures before and after total knee replacement.

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Motion Analysis Laboratory, Department of Human Physiology, University of Oregon, Eugene, OR 97403, USA.


The purpose of this study was to assess the use of a multivariate statistical method to rank clinical and gait variables, thus describing a ranking of patient dysfunction prior to and following total knee replacement (TKR) surgery. Twenty end-stage knee osteoarthritis (KOA) subjects scheduled for TKR and 20 healthy controls performed level walking and stair ascent twice: pre- (P1) and 6 months post-surgery (P2). Clinical and gait measures were entered into a principle component analysis (PCA) to determine orthogonal principle components (PCs). The PCs were entered into a discriminant function analysis to determine the best predictors of group membership. The PCA extracted three PCs for both the P1 and P2 data sets. Three orthogonal dimensions were formed: "knee dysfunction", "gait dysfunction", and "stair ascent dysfunction". For P1 the "knee dysfunction" dimension composed of both subjective and objective measures, best discriminated between end-stage knee osteoarthritis patients and controls. For P2, the "stair ascent dysfunction" dimension best discriminated between 6 months post-TKR patients and controls. The results of this study suggest that a multivariate statistical method provides a clinically relevant ranking of patient dysfunction prior to and following TKR. This ranking of dysfunction could serve to identify rehabilitation priorities.

[Indexed for MEDLINE]

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