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J Pediatr. 2009 Aug;155(2):250-3. doi: 10.1016/j.jpeds.2009.02.038. Epub 2009 May 21.

Effectiveness of adenotonsillectomy in PFAPA syndrome: a randomized study.

Author information

1
Department of Otorhinolaryngology-Head and Neck Surgery, Ospedale San Gerardo, University of Milano-Bicocca, DNTB Monza, Italy. werner.garavello@unimib.it

Abstract

OBJECTIVE:

To evaluate whether adenotonsillectomy leads to complete resolution in children with PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) syndrome.

STUDY DESIGN:

Thirty-nine children with PFAPA syndrome were randomized to either adenotonsillectomy (surgery group; n = 19) or expectant management (control group; n = 20). All patients were then invited prospectively to record all PFAPA episodes, and were evaluated clinically every 3 months for 18 months after randomization.

RESULTS:

The proportion of patients experiencing complete resolution was 63% in the surgery group and 5% in the control group (P < .001). The mean (+/- standard deviation) number of episodes recorded during the study period was 0.7 +/- 1.2 in the surgery group and 8.1 +/- 3.9 in the control group (P < .001). The episodes were less severe in the surgery group.

CONCLUSIONS:

Adenotonsillectomy is an effective treatment strategy for children with PFAPA syndrome.

PMID:
19464029
DOI:
10.1016/j.jpeds.2009.02.038
[Indexed for MEDLINE]
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