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Fertil Steril. 2010 Jun;94(1):216-20. doi: 10.1016/j.fertnstert.2009.02.078. Epub 2009 May 21.

An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic ovary syndrome.

Author information

1
Research and Clinical Center for Infertility, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran. nikanresearch@gmail.com

Abstract

OBJECTIVE:

To compare the effect of clomiphene citrate, metformin, and lifestyle modification on treatment of patients with polycystic ovary syndrome (PCOS).

DESIGN:

Prospective randomized double-blind study.

SETTING:

University-based infertility clinic and research center.

PATIENT(S):

Three hundred forty-three overweight infertile women with PCOS.

INTERVENTION(S):

The participating women were assigned to four groups: clomiphene (n = 90), metformin (n = 90), clomiphene + metformin (n = 88), and lifestyle modification (n = 75). The patients in each group received standardized dietary and exercise advice from a dietitian.

MAIN OUTCOME MEASURE(S):

The primary outcome variables were change in menstrual cycle, waist circumference measurements, endocrine parameters, and lipid profile. The main secondary outcome variable was clinical pregnancy rate.

RESULT(S):

The clinical pregnancy rate was 12.2% in clomiphene group, 14.4% in metformin group, 14.8% in clomiphene + metformin group, and 20% in lifestyle modification group. Lifestyle modification group achieved a significant reduction in waist circumference, total androgen, and lipid profile.

CONCLUSION(S):

Lifestyle modification improves the lipid profile in PCOS patients. Therefore, lifestyle modification may be used as the first line of ovulation induction in PCOS patients.

[Indexed for MEDLINE]

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