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Protein Seq Data Anal. 1991 Aug;4(2):111-7.

Sequence analysis of firefly luciferase family reveals a conservative sequence motif.

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Protein Engineering Research Institute, Osaka, Japan.


A conservative sequence motif was extracted from an alignment of the firefly luciferase family. AngR derived from a pathogenic bacterium and acetyl-CoA synthetases derived from two ascomycete fungi were identified as members of the firefly luciferase family by a homology search with the motif and other sequence comparison analyses. The motif sequence shares several characteristics with the phosphate-binding sites of phosphoproteins and nucleotide-binding proteins. A multiple alignment and an unrooted phylogenetic tree were constructed for the investigation of evolutionary relationships within the firefly luciferase family.

[Indexed for MEDLINE]

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