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Cell Death Differ. 2010 Feb;17(2):209-14. doi: 10.1038/cdd.2009.58. Epub 2009 May 22.

miR-10 in development and cancer.

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  • 1Biotech Research and Innovation Centre and Center for Epigenetics, University of Copenhagen, Ole Maal√łes Vej 5, DK-2200 Copenhagen, Denmark. anders.lund@bric.dk

Abstract

The microRNA (miRNA) miR-10 family has attracted attention because of its conservation and the position of the miR-10 genes within the Hox clusters of developmental regulators. In several species, miR-10 is coexpressed with a set of Hox genes and has been found to regulate the translation of Hox transcripts. In addition, members of the miR-10 family are de-regulated in several cancer forms. Aside from acting in translational repression, miR-10 was recently found to bind a group of transcripts containing a terminal oligo-pyrimidine (TOP) motif and to induce their translation, thereby adding a new function to the miRNA repertoire.

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