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Nature. 2009 May 21;459(7245):379-85. doi: 10.1038/nature08147.

Emerging roles for lipids in shaping membrane-protein function.

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1
Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA. phillips@pboc.caltech.edu

Abstract

Studies of membrane proteins have revealed a direct link between the lipid environment and the structure and function of some of these proteins. Although some of these effects involve specific chemical interactions between lipids and protein residues, many can be understood in terms of protein-induced perturbations to the membrane shape. The free-energy cost of such perturbations can be estimated quantitatively, and measurements of channel gating in model systems of membrane proteins with their lipid partners are now confirming predictions of simple models.

PMID:
19458714
PMCID:
PMC3169427
DOI:
10.1038/nature08147
[Indexed for MEDLINE]
Free PMC Article
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