Format

Send to

Choose Destination
Cancer Lett. 2009 Oct 18;284(1):71-9. doi: 10.1016/j.canlet.2009.04.020. Epub 2009 May 19.

Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling.

Author information

1
Center for Genetic and Regenerative Medicine, Nagoya University Hospital, Nagoya, Japan.

Abstract

The response of cancer patients to interferon (IFN) treatment is long-lasting, indicating that IFN may act on small cancer stem cell populations. Glioma-initiating cells (GICs) can self-renew and induce the formation of heterogeneously differentiated tumor cells and are resistant to chemotherapeutic agents like temozolomide. In this study, we showed that via STAT3 signaling, IFN-beta suppressed the proliferation, self-renewal, and tumorigenesis of GICs, induced their terminal differentiation to mature oligodendroglia-like cells, and exhibited synergistic cytotoxicity with temozolomide. Therefore, IFN may be a potential therapeutic agent for inducing the terminal differentiation of GICs.

PMID:
19457609
DOI:
10.1016/j.canlet.2009.04.020
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center