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Neuroimage. 2009 May 15;46(1):133-43. doi: 10.1016/j.neuroimage.2009.01.033. Epub 2009 Feb 3.

Real-time imaging of human brain function by near-infrared spectroscopy using an adaptive general linear model.

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University of Pittsburgh Medical Center, Magnetic Resonance Research Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA.


Near-infrared spectroscopy is a non-invasive neuroimaging method which uses light to measure changes in cerebral blood oxygenation associated with brain activity. In this work, we demonstrate the ability to record and analyze images of brain activity in real-time using a 16-channel continuous wave optical NIRS system. We propose a novel real-time analysis framework using an adaptive Kalman filter and a state-space model based on a canonical general linear model of brain activity. We show that our adaptive model has the ability to estimate single-trial brain activity events as we apply this method to track and classify experimental data acquired during an alternating bilateral self-paced finger tapping task.

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