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Rev Clin Esp. 2009 Apr;209(4):176-9.

[Agranulocytosis from metamizole: a potential problem for the British population].

[Article in Spanish]

Author information

1
Unidad de Medicina Interna. Area de Medicina. Hospital Costa del Sol. Marbella. Málaga. España. luismr@hcs.es

Abstract

OBJECTIVE:

Analyze the clinical and epidemiological features of this adverse effect and assess its incidence in the general population, especially in the British one.

METHODS:

A descriptive, retrospective analysis of all the patients discharged at Hospital Costa del Sol (Marbella) with a main diagnosis of dipyrone-related agranulocytosis in the Minimum Basic Data Set (MBDS) from January 1998 to December 2003. Neutropenia was defined as severe (neutrophils lower than 500/ml), moderate (500-1000/ml) and mild (1000-1500/ml).

RESULTS:

13 patients developed dipyrone-related agranulocytosis, 8 of them foreign (61.5%) and 5 from United Kingdom. The rate of events was 8.33/106 inhabitants/year. With regard to British population registered in the area, the estimated rate of events was 20.4 cases/106 inhabitants/year.

CONCLUSION:

Dipyrone-related agranulocytosis is an adverse effect more frequent in British population, and its use must be avoided.

PMID:
19457324
[Indexed for MEDLINE]

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