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Rev Clin Esp. 2009 Apr;209(4):176-9.

[Agranulocytosis from metamizole: a potential problem for the British population].

[Article in Spanish]

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Unidad de Medicina Interna. Area de Medicina. Hospital Costa del Sol. Marbella. Málaga. España.



Analyze the clinical and epidemiological features of this adverse effect and assess its incidence in the general population, especially in the British one.


A descriptive, retrospective analysis of all the patients discharged at Hospital Costa del Sol (Marbella) with a main diagnosis of dipyrone-related agranulocytosis in the Minimum Basic Data Set (MBDS) from January 1998 to December 2003. Neutropenia was defined as severe (neutrophils lower than 500/ml), moderate (500-1000/ml) and mild (1000-1500/ml).


13 patients developed dipyrone-related agranulocytosis, 8 of them foreign (61.5%) and 5 from United Kingdom. The rate of events was 8.33/106 inhabitants/year. With regard to British population registered in the area, the estimated rate of events was 20.4 cases/106 inhabitants/year.


Dipyrone-related agranulocytosis is an adverse effect more frequent in British population, and its use must be avoided.

[Indexed for MEDLINE]

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