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Clin Microbiol Infect. 2009 Dec;15(12):1178-81. doi: 10.1111/j.1469-0691.2009.02783.x. Epub 2009 May 16.

Molecular characterization of resistance to rifampicin in clinical isolates of Neisseria meningitidis.

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1
Neisseria Unit, Institute Pasteur, Paris, France. skoczek@cls.edu.pl

Abstract

Among 3904 meningococcal isolates collected between October 2002 and June 2007 by the French Meningococcal Reference Centre, eight (0.20%) were resistant to rifampicin (Rif-R; MIC >1 mg/L) and 27 (0.69%) were intermediate-resistant to rifampicin (Rif-I; MICs between 0.38 mg/L and 1 mg/L) according to the E-test method. The MICs determined by agar dilution were lower, eliminating the E-test intermediate category. All Rif-R isolates had mutations in the rpoB gene, resulting in substitutions at or near amino acid position 552, which were absent in non-resistant isolates. These data suggest that a rifampicin clinical breakpoint of 1.0 mg/L should be adopted for Neisseria meningitidis.

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