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Nippon Ganka Gakkai Zasshi. 2009 Apr;113(4):492-7.

[Intravitreal tissue plasminogen activator for treatment of central retinal vein occlusion associated with diabetic retinopathy].

[Article in Japanese]

Author information

  • 1Department of Ophthalmology & Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Japan kiyoshisuzuma@yahoo.co.jp

Abstract

PURPOSE:

To evaluate the effects of intravitreal injection of tissue plasminogen activator (tPA) on central retinal vein occlusion(CRVO) associated with diabetic retinopathy (DR).

METHODS:

A retrospective study of 42 eyes of 42 patients(mean age: 68 years, female/male = 20/22, 5 eyes associated with DR) with macular edema caused by CRVO treated with tPA. Best corrected visual acuity (BVCA or logarithm of the minimal angle of resolution: logMAR), macular thickness was mea sured by optical coherence tomography (OCT), and several variables were evaluated.

RESULTS:

The mean logMAR and macular thickness improved significantly in the DR (-) group, but, no significant changes were observed in the DR (+) group. Post-operative posterior vitreous detachment (PVD) developed in 62% of the DR (-) group and none of the DR (+) group.

CONCLUSION:

There may be no beneficial effects of intravitreal tPA on CRVO associated with diabetic retinopathy.

PMID:
19455970
[PubMed - indexed for MEDLINE]
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