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Nippon Ganka Gakkai Zasshi. 2009 Apr;113(4):492-7.

[Intravitreal tissue plasminogen activator for treatment of central retinal vein occlusion associated with diabetic retinopathy].

[Article in Japanese]

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  • 1Department of Ophthalmology & Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Japan



To evaluate the effects of intravitreal injection of tissue plasminogen activator (tPA) on central retinal vein occlusion(CRVO) associated with diabetic retinopathy (DR).


A retrospective study of 42 eyes of 42 patients(mean age: 68 years, female/male = 20/22, 5 eyes associated with DR) with macular edema caused by CRVO treated with tPA. Best corrected visual acuity (BVCA or logarithm of the minimal angle of resolution: logMAR), macular thickness was mea sured by optical coherence tomography (OCT), and several variables were evaluated.


The mean logMAR and macular thickness improved significantly in the DR (-) group, but, no significant changes were observed in the DR (+) group. Post-operative posterior vitreous detachment (PVD) developed in 62% of the DR (-) group and none of the DR (+) group.


There may be no beneficial effects of intravitreal tPA on CRVO associated with diabetic retinopathy.

[PubMed - indexed for MEDLINE]
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