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J Ethnopharmacol. 2009 Jul 30;124(3):544-50. doi: 10.1016/j.jep.2009.05.005. Epub 2009 May 18.

Effect of shanzha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet.

Author information

1
Department of Pharmacy, Tajen University, Yen-Pou, Ping Tung Shien, 90701, Taiwan, ROC.

Abstract

AIM:

The present study is designed to investigate the effect of shanzha (Crataegus pinnatifida) on obesity or dyslipidemia induced by high-fat diet in hamsters and characterize the role of PPARalpha in this action of shanzha.

MATERIALS AND METHODS:

We induced dyslipidemia and obesity in hamsters using high-fat diet and treated hamsters with shanzha or vehicle for 7 days. We measured the body weight, adipose tissue weights, and food intake of hamsters. Plasma total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) were determined at the beginning and end of this treatment. Effect of shanzha on adipogenesis was examined in vitro and change of PPARalpha was analyzed using Western blot.

RESULTS:

The food intake, body weights, and weights of both brown and white adipose tissues were markedly reduced in hamsters receiving shanzha as compared with the vehicle-treated control. Plasma levels of TC, TG and LDL-C were decreased by this shanzha treatment while HDL-C was elevated. The effects of shanzha were reversed by the combined treatment with PPARalpha antagonist, MK886. Shanzha inhibited the fat droplet accumulation in 3T3-L1 adipocytes in a dose-dependent manner and this effect was abolished by MK886. Western blot results showed activation of PPARalpha by shanzha in hamster adipose tissue.

CONCLUSION:

We suggest that shanzha could activate PPARalpha to improve dyslipidemia or obesity.

PMID:
19454308
DOI:
10.1016/j.jep.2009.05.005
[Indexed for MEDLINE]

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