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J Sex Med. 2009 Jun;6(6):1561-1568. doi: 10.1111/j.1743-6109.2009.01242.x. Epub 2009 Apr 23.

Sexual dysfunction is frequent in premenopausal women with diabetes, obesity, and hypothyroidism, and correlates with markers of increased cardiovascular risk. A preliminary report.

Author information

1
Università degli Studi di Milano-Dipartimento di Medicina, Chirurgia e Odontoiatria, Milano, Italy;; Ospedale San Paolo-Medicina 2a, Milano, Italy.
2
Università degli Studi di Milano-Dipartimento di Medicina, Chirurgia e Odontoiatria, Milano, Italy.
3
Ospedale San Paolo-Medicina 2a, Milano, Italy.
4
Università degli Studi di Milano-Dipartimento di Medicina, Chirurgia e Odontoiatria, Milano, Italy;; Ospedale San Paolo-Medicina 2a, Milano, Italy. Electronic address: antonio.pontiroli@unimi.it.

Abstract

INTRODUCTION:

Female sexual dysfunction (FSD) is characterized by reduced sexual appetite and altered psychologic and physiologic response to sexual intercourse; it is reported to be frequent in diabetes mellitus, but no data have been reported in thyroid disorders.

AIMS:

To compare the prevalence of FSD in diabetic, in obese, and in hypothyroid women vs. healthy women, and to correlate FSD with endocrine and metabolic profiles.

METHODS:

We evaluated, through a questionnaire (Female Sexual Function Index [FSFI]), the prevalence of FSD in 91 women affected by diabetes mellitus, obesity, or hypothyroidism, and in 36 healthy women, all aged 22-51 years and in premenopausal state.

MAIN OUTCOME MEASURES:

FSFI score, endocrine and metabolic parameters (triglycerides, high-density lipoprotein [HDL] and low-density lipoprotein [LDL] cholesterol, free-triiodothyronine (FT3), free-thyroxine (FT4), thyroid stimulating hormone [TSH], 17-beta-estradiol, testosterone, glycated hemoglobin 1c (HbA1c), thyroid autoantibodies, E-selectin, P-selectin, intercellular adhesion molecule-1 [ICAM-1], plasminogen-activator inhibitor-1 [PAI-1]), and anthropometric parameters (body mass index, waist, blood pressure [BP]).

RESULTS:

A reduced FSFI score was more frequent in diabetic, obese, and hypothyroid women vs. healthy women (P < 0.01). In the different groups of women, FSFI score was inversely correlated (pairwise correlation) with at least one of the following: HbA1c, TSH, LDL-cholesterol, PAI-1, diastolic BP, presence of thyroid Ab, and directly correlated with HDL-cholesterol (always P < 0.05 or less). At stepwise regression analysis, HDL-cholesterol (protective) and HbA1c, LDL-cholesterol, PAI-1, and diastolic BP (negatively) predicted reduced FSFI score.

CONCLUSION:

These data indicate an increased prevalence of sexual dysfunction in diabetic, in obese, and in hypothyroid women, associated with markers of cardiovascular risk.

[Indexed for MEDLINE]

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