Send to

Choose Destination
See comment in PubMed Commons below
J Eur Acad Dermatol Venereol. 2009 Oct;23(10):1123-7. doi: 10.1111/j.1468-3083.2009.03292.x. Epub 2009 Apr 30.

Immunopathogenesis of psoriasis: focus on natural killer T cells.

Author information

Department of Dermatovenereology, Clinical Hospital Center Rijeka, University of Rijeka, Rijeka, Croatia.


Psoriasis is a common inflammatory skin disease triggered by dysregulated immune response and characterized by hyperproliferation and altered differentiation of keratinocytes. Formation of psoriatic lesions is thought to be elicited by the complex cellular and cytokine network arising from the pathogenic interactions between keratinocytes and components of innate and acquired immune system. Natural killer T (NKT) cells are a heterogenous T-cell lineage that has been implicated in the pathogenesis of various autoimmune diseases including psoriasis. Due to the numerous functions of NKT cells that link innate and adaptive immunity, their role in psoriasis is complex and still elusive. We summarize the currently available literature data on this issue and discuss the possible role of NKT cells in the immunopathogenesis of this autoimmune disease.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center