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J Anat. 2009 Jul;215(1):3-13. doi: 10.1111/j.1469-7580.2008.01034.x. Epub 2009 Apr 22.

Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation.

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  • 1Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK.

Abstract

Cell adhesion in endometrial epithelium is regulated to maintain the continuity and protectiveness of the luminal covering cell layer while permitting interstitial implantation of the embryo during a restricted period of about 4 days. Many apparently normal embryos fail to implant, and epithelial-embryo adhesion remains a poorly understood phenomenon. After menstruation, epithelial regeneration occurs by epiboly from the basal residues of glands, an activity that requires migration on extracellular matrix as well as cell-cell cohesion. Here we review current knowledge of adhesion molecules in the epithelium.

PMID:
19453302
PMCID:
PMC2714633
DOI:
10.1111/j.1469-7580.2008.01034.x
[PubMed - indexed for MEDLINE]
Free PMC Article
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