Sensitivity of α-thrombin concentration to rate constant (

*k*_{i}) variation: time series of thrombin concentrations when varying

*k*_{36}or

*k*_{41}. Panel A: variation of

*k*_{36} (governing the formation of TF · VIIa · Xa · TFPI from the reaction of TF · VIIa · Xa with TFPI) from 3.2 × 10

^{7} M

^{−1}s

^{−1} (dotted curve) to 3.2 × 10

^{8} M

^{−1}s

^{−1} (standard model value, dashed curve) to 3.2 × 10

^{9} M

^{−1}s

^{−1} (dash dot curve). The standard deviation associated with the mean thrombin concentration at each time point is shown as a solid line. Panel B: variation of

*k*_{41} (governing the reaction of AT with α-IIa) from 7.2 × 10

^{2} M

^{−1} s

^{−1} (dotted curve) to 7.1 × 10

^{3} M

^{−1}s

^{−1} (standard model value, dashed curve) to 7.1 × 10

^{4} M

^{−1}s

^{−1} (dash dot curve). The standard deviation associated with the mean thrombin concentration at each time point is shown as a solid line. Panel C: the coefficient of variation (

) at each time point is plotted for

*k*_{36} and

*k*_{41}. The time-averaged coefficient of variation values (defined as the mean of the coefficient of variations across the 20-min simulation) are also shown for each rate constant.

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