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Eur J Dermatol. 2009 Jul-Aug;19(4):368-71. doi: 10.1684/ejd.2009.0694. Epub 2009 May 18.

Two cases of childhood bullous pemphigoid.

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Department of Dermatology, Saitama Medical University, 38 Morohongo, Moroyamamachi, Iruma-gun, Saitama, Japan, 350-0495.


This report describes two cases of childhood bullous pemphigoid (BP). These cases showed vesiculobullous lesions on the face, trunk, extremities, hands and feet. Histopathological analysis of skin lesions showed infiltration of numerous lymphocytes and eosinophils in the superficial dermis. Immunofluorescent analysis showed a linear IgG deposit along the basement membrane zone. In both cases ELISA showed circulating IgG autoantibodies against the NC16A domain of 180-KDa BP antigen (BP180). Both IgG and IgA (faint deposit) autoantibodies against the NC16A domain of BP180 were detected by an immunoblot analysis in both cases. Both patients showed a similar clinical course with a rapid remission after treatment with topical corticosteroids. Both patients received vaccinations within two weeks before the appearance of the eruption. These cases were considered to be childhood BP presenting both IgG and IgA autoantibodies against the NC16A domains of BP180.

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