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Cell. 2009 May 15;137(4):604-6. doi: 10.1016/j.cell.2009.04.052.

The CULt of caspase-8 ubiquitination.

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1
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.

PMID:
19450509
DOI:
10.1016/j.cell.2009.04.052
[Indexed for MEDLINE]
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